› 6bbj

Electron Microscopy
3.8Å resolution

Xenopus Tropicalis TRPV4

Released:
DOI: 10.2210/pdb6bbj/pdb
PDB entry 6bbj coloured by chain, front view.
PDB entry 6bbj coloured by chain, side view.
PDB entry 6bbj coloured by chain, top view.
Source organism: Xenopus tropicalis
Primary publication:
Cryo-EM and X-ray structures of TRPV4 reveal insight into ion permeation and gating mechanisms.
Deng Z, Paknejad N, Maksaev G, Sala-Rabanal M, Nichols CG, Hite RK, Yuan P
Nat Struct Mol Biol 25 252-260 (2018)
PMID: 29483651
Related structures: EMD-7075

Function and Biology Details

Biochemical function:
Biological process:
Cellular component:
Sequence domains:

Structure analysis Details

Assembly composition:
homo tetramer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-166458 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Transient receptor potential cation channel, subfamily V, member 4 Chains: A, B, C, D
Molecule details ›
Chains: A, B, C, D
Length: 868 amino acids
Theoretical weight: 99.09 KDa
Source organism: Xenopus tropicalis
Expression system: Pichia

Ligands and Environments

No bound ligands
No modified residues

Experiments and Validation Details

Entry percentile scores
Resolution: 3.8Å
Relevant EMDB volumes: EMD-7075
Expression system: Pichia

Quick links

Citations

38 review citations

Discoveries in structure and physiology of mechanically activated ion channels.
Kefauver et al. (2020)
37 more

23 mentions without citation

Structural mechanisms of transient receptor potential ion channels.
Cao E. (2020)
22 more