› 6bhc

X-ray diffraction
2.3Å resolution

Crystal structure of pseduokinase PEAK1 (Sugen Kinase 269)

Released:
DOI: 10.2210/pdb6bhc/pdb
PDB entry 6bhc coloured by chain, front view.
PDB entry 6bhc coloured by chain, side view.
PDB entry 6bhc coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
The crystal structure of pseudokinase PEAK1 (Sugen kinase 269) reveals an unusual catalytic cleft and a novel mode of kinase fold dimerization.
Ha BH, Boggon TJ
J Biol Chem 293 1642-1650 (2018)
PMID: 29212708

Function and Biology Details

Reaction catalysed: 
ATP + a [protein]-L-tyrosine = ADP + a [protein]-L-tyrosine phosphate
Biochemical function:
Biological process:
Cellular component:
  • not assigned
Sequence domains:

Structure analysis Details

Assembly composition:
homo dimer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-190658 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Inactive tyrosine-protein kinase PEAK1 Chain: A
Molecule details ›
Chain: A
Length: 438 amino acids
Theoretical weight: 50.15 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli BL21(DE3)
UniProt:
  • Canonical: Q9H792 (Residues: 1272-1743; Coverage: 25%)
Gene names: KIAA2002, PEAK1
Sequence domains: Protein kinase domain

Ligands and Environments

No bound ligands
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: APS BEAMLINE 24-ID-E
Unit cell:
a: 58.923Å b: 72.724Å c: 103.192Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.196 0.194 0.234
Expression system: Escherichia coli BL21(DE3)

Quick links

Citations

4 review citations

New insights into the structure of PINK1 and the mechanism of ubiquitin phosphorylation.
Rasool et al. (2018)
3 more

7 mentions without citation

Prospects for pharmacological targeting of pseudokinases.
Kung et al. (2019)
6 more