› 6bhu

Electron Microscopy
3.14Å resolution

Cryo-EM structure of ATP-bound, outward-facing bovine multidrug resistance protein 1 (MRP1)

Released:
DOI: 10.2210/pdb6bhu/pdb
PDB entry 6bhu coloured by chain, front view.
PDB entry 6bhu coloured by chain, side view.
PDB entry 6bhu coloured by chain, top view.
Source organism: Bos taurus
Primary publication:
ATP Binding Enables Substrate Release from Multidrug Resistance Protein 1.
Johnson ZL, Chen J
Cell 172 81-89.e10 (2018)
PMID: 29290467
Related structures: EMD-7099

Function and Biology Details

Reactions catalysed: 
ATP + H(2)O + xenobiotic(Side 1) = ADP + phosphate + xenobiotic(Side 2)
ATP + H(2)O + glutathione-S-conjugate(Side 1) = ADP + phosphate + glutathione-S-conjugate(Side 2)
Biochemical function:
Biological process:
Cellular component:
Sequence domains:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-184617 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Multidrug resistance-associated protein 1 Chain: A
Molecule details ›
Chain: A
Length: 1659 amino acids
Theoretical weight: 183.07 KDa
Source organism: Bos taurus
Expression system: Homo sapiens
UniProt:
  • Canonical: Q8HXQ5 (Residues: 1-1530; Coverage: 100%)
Gene names: ABCC1, MRP1
Sequence domains:

Ligands and Environments

3 bound ligands:
Ligand ATP 2 x ATP
Ligand MG 2 x MG
Ligand CLR 3 x CLR
No modified residues

Experiments and Validation Details

Entry percentile scores
Resolution: 3.14Å
Relevant EMDB volumes: EMD-7099
Expression system: Homo sapiens

Quick links

Citations

15 review citations

Emerging Diversity in Lipid-Protein Interactions.
Corradi et al. (2019)
14 more

27 mentions without citation

Structural and functional diversity calls for a new classification of ABC transporters.
Thomas et al. (2020)
26 more