› 6bkl

X-ray diffraction
2Å resolution

Influenza A M2 transmembrane domain bound to rimantadine

Released:
DOI: 10.2210/pdb6bkl/pdb
PDB entry 6bkl coloured by chain, front view.
PDB entry 6bkl coloured by chain, side view.
PDB entry 6bkl coloured by chain, top view.
Source organism: Influenza A virus
Primary publication:
Inhibitors of the M2 Proton Channel Engage and Disrupt Transmembrane Networks of Hydrogen-Bonded Waters.
Thomaston JL, Polizzi NF, Konstantinidi A, Wang J, Kolocouris A, DeGrado WF
J Am Chem Soc 140 15219-15226 (2018)
PMID: 30165017

Function and Biology Details

Biochemical function:
Biological process:
Cellular component:
Sequence domain:

Structure analysis Details

Assembly composition:
homo tetramer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-192958 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Matrix protein 2 Chains: A, B, C, D, E, F, G, H
Molecule details ›
Chains: A, B, C, D, E, F, G, H
Length: 27 amino acids
Theoretical weight: 2.75 KDa
Source organism: Influenza A virus
Expression system: Not provided
UniProt:
  • Canonical: Q9Q0L9 (Residues: 22-46; Coverage: 26%)
Gene name: M

Ligands and Environments

2 bound ligands:
Ligand EU7 2 x EU7
Ligand RIM 2 x RIM
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: ALS BEAMLINE 8.3.1
Spacegroup: P21
Unit cell:
a: 36.46Å b: 47.84Å c: 48.53Å
α: 90° β: 96.76° γ: 90°
R-values:
R R work R free
0.192 0.186 0.244
Expression system: Not provided

Quick links

Citations

8 review citations

Put a cork in it: Plugging the M2 viral ion channel to sink influenza.
Jalily et al. (2020)
7 more

9 mentions without citation

Recent Advances in Application of Computer-Aided Drug Design in Anti-Influenza A Virus Drug Discovery.
Yu et al. (2022)
8 more