› 6bms

X-ray diffraction
2.44Å resolution

Palmitoyltransferase structure

Released:
DOI: 10.2210/pdb6bms/pdb
PDB entry 6bms coloured by chain, front view.
PDB entry 6bms coloured by chain, side view.
PDB entry 6bms coloured by chain, top view.
Source organism: Danio rerio
Primary publication:
Fatty acyl recognition and transfer by an integral membrane S-acyltransferase.
Rana MS, Kumar P, Lee CJ, Verardi R, Rajashankar KR, Banerjee A
Science 359 (2018)
PMID: 29326245

Function and Biology Details

Reaction catalysed: 
Palmitoyl-CoA + [protein]-L-cysteine = [protein]-S-palmitoyl-L-cysteine + CoA
Biochemical function:
Biological process:
Cellular component:
Sequence domain:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-123351 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Palmitoyltransferase ZDHHC15B Chains: A, D
Molecule details ›
Chains: A, D
Length: 341 amino acids
Theoretical weight: 39.68 KDa
Source organism: Danio rerio
Expression system: Komagataella phaffii GS115
UniProt:
  • Canonical: F1QXD3 (Residues: 1-332; Coverage: 100%)
Gene name: zdhhc15b
Sequence domains: DHHC palmitoyltransferase

Ligands and Environments

5 bound ligands:
Ligand ZN 4 x ZN
Ligand LMT 5 x LMT
Ligand PLM 2 x PLM
Ligand POV 1 x POV
Ligand PO4 3 x PO4
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: APS BEAMLINE 22-ID
Spacegroup: P42212
Unit cell:
a: 186.402Å b: 186.402Å c: 90.177Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.234 0.232 0.261
Expression system: Komagataella phaffii GS115

Quick links

Citations

31 review citations

Identification of bioactive metabolites using activity metabolomics.
Rinschen et al. (2019)
30 more

5 mentions without citation

Insights into auto-S-fatty acylation: targets, druggability, and inhibitors.
Hu et al. (2021)
4 more