› 6bnf

X-ray diffraction
2.33Å resolution

Crystal structure of the intrinsic colistin resistance enzyme ICR(Mc) from Moraxella catarrhalis, catalytic domain, mono-zinc complex

Released:
DOI: 10.2210/pdb6bnf/pdb
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PDB entry 6bnf coloured by chain, front view.
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PDB entry 6bnf coloured by chain, top view.
Source organism: Moraxella sp. HMSC061H09
Primary publication:
Substrate Recognition by a Colistin Resistance Enzyme from Moraxella catarrhalis.
Stogios PJ, Cox G, Zubyk HL, Evdokimova E, Wawrzak Z, Wright GD, Savchenko A
ACS Chem Biol 13 1322-1332 (2018)
PMID: 29631403

Function and Biology Details

Biochemical function:
Biological process:
  • not assigned
Cellular component:
  • not assigned
Sequence domains:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-103442 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Phosphoethanolamine transferase Chain: A
Molecule details ›
Chain: A
Length: 344 amino acids
Theoretical weight: 37.97 KDa
Source organism: Moraxella sp. HMSC061H09
Expression system: Escherichia coli
UniProt:
  • Canonical: A0A1E9VP98 (Residues: 235-578; Coverage: 60%)
Gene name: HMPREF2573_04170
Sequence domains: Sulfatase
Structure domains: Alkaline Phosphatase, subunit A

Ligands and Environments

5 bound ligands:
Ligand PO4 1 x PO4
Ligand ZN 1 x ZN
Ligand SO4 1 x SO4
Ligand ACT 6 x ACT
Ligand GOL 3 x GOL
No modified residues

Experiments and Validation Details

wwPDB Validation report is not available for this entry.
X-ray source: APS BEAMLINE 21-ID-D
Spacegroup: P4132
Unit cell:
a: 148.272Å b: 148.272Å c: 148.272Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.21 0.208 0.248
Expression system: Escherichia coli

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Citations

7 citation in other articles

Overcoming Fungal Echinocandin Resistance through Inhibition of the Non-essential Stress Kinase Yck2.
Caplan et al. (2020)
6 more

2 mentions without citation

Phosphoethanolamine Transferases as Drug Discovery Targets for Therapeutic Treatment of Multi-Drug Resistant Pathogenic Gram-Negative Bacteria.
Thai et al. (2023)
1 more

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