› 6bnm

X-ray diffraction
1.9Å resolution

Crystal Structure of the P-Rex2 PH domain

Released:
DOI: 10.2210/pdb6bnm/pdb
PDB entry 6bnm coloured by chain, front view.
PDB entry 6bnm coloured by chain, side view.
PDB entry 6bnm coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
Structural and biochemical characterization of the pleckstrin homology domain of the RhoGEF P-Rex2 and its regulation by PIP3.
Cash JN, Sharma PV, Tesmer JJG
J. Struct. Biol. 1 (2019)

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
  • not assigned
Sequence domains:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-180716 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Phosphatidylinositol 3,4,5-trisphosphate-dependent Rac exchanger 2 protein Chain: A
Molecule details ›
Chain: A
Length: 162 amino acids
Theoretical weight: 19.07 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli 'BL21-Gold(DE3)pLysS AG'
UniProt:
  • Canonical: Q70Z35 (Residues: 219-377; Coverage: 10%)
Gene names: DEPDC2, PREX2
Sequence domains: PH domain
Structure domains: Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)

Ligands and Environments

1 bound ligand:
Ligand CL 4 x CL
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: APS BEAMLINE 21-ID-D
Spacegroup: P3121
Unit cell:
a: 60.105Å b: 60.105Å c: 86.238Å
α: 90° β: 90° γ: 120°
R-values:
R R work R free
0.193 0.191 0.232
Expression system: Escherichia coli 'BL21-Gold(DE3)pLysS AG'

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