› 6bo8

Electron Microscopy
3.6Å resolution

Cryo-EM structure of human TRPV6 in nanodiscs

Released:
DOI: 10.2210/pdb6bo8/pdb
PDB entry 6bo8 coloured by chain, front view.
PDB entry 6bo8 coloured by chain, side view.
PDB entry 6bo8 coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
Opening of the human epithelial calcium channel TRPV6.
McGoldrick LL, Singh AK, Saotome K, Yelshanskaya MV, Twomey EC, Grassucci RA, Sobolevsky AI
Nature 553 233-237 (2018)
PMID: 29258289
Related structures: EMD-7120

Function and Biology Details

Biochemical function:
Biological process:
Cellular component:
Sequence domains:

Structure analysis Details

Assembly composition:
homo tetramer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-190512 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Transient receptor potential cation channel subfamily V member 6 Chains: A, B, C, D
Molecule details ›
Chains: A, B, C, D
Length: 742 amino acids
Theoretical weight: 85.17 KDa
Source organism: Homo sapiens
Expression system: Homo sapiens
UniProt:
  • Canonical: Q9H1D0 (Residues: 41-765; Coverage: 95%)
Gene names: ECAC2, TRPV6
Sequence domains:

Ligands and Environments

No bound ligands
No modified residues

Experiments and Validation Details

Entry percentile scores
Resolution: 3.6Å
Relevant EMDB volumes: EMD-7120
Expression system: Homo sapiens

Quick links

Citations

32 review citations

Transient Receptor Potential Channels and Calcium Signaling.
Vangeel et al. (2019)
31 more

22 mentions without citation

Structural insights into the gating mechanisms of TRPV channels.
Pumroy et al. (2020)
21 more