› 6bpq

Electron Microscopy
4.1Å resolution

Structure of the cold- and menthol-sensing ion channel TRPM8

Released:
DOI: 10.2210/pdb6bpq/pdb
PDB entry 6bpq coloured by chain, front view.
PDB entry 6bpq coloured by chain, side view.
PDB entry 6bpq coloured by chain, top view.
Source organism: Ficedula albicollis
Primary publication:
Structure of the cold- and menthol-sensing ion channel TRPM8.
Yin Y, Wu M, Zubcevic L, Borschel WF, Lander GC, Lee SY
Science 359 237-241 (2018)
PMID: 29217583
Related structures: EMD-7127

Function and Biology Details

Biochemical function:
Biological process:
Cellular component:
Sequence domains:

Structure analysis Details

Assembly composition:
homo tetramer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-197530 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Transient receptor potential cation channel subfamily M member 8 Chains: A, B, C, D
Molecule details ›
Chains: A, B, C, D
Length: 950 amino acids
Theoretical weight: 107.85 KDa
Source organism: Ficedula albicollis
Expression system: Homo sapiens
UniProt:
  • Canonical: U3JD03 (Residues: 145-1091; Coverage: 82%)
Sequence domains:

Ligands and Environments

No bound ligands
No modified residues

Experiments and Validation Details

Entry percentile scores
Resolution: 4.1Å
Relevant EMDB volumes: EMD-7127
Expression system: Homo sapiens

Quick links

Citations

53 review citations

Cannabinoid Ligands Targeting TRP Channels.
Muller et al. (2018)
52 more

33 mentions without citation

A structural overview of the ion channels of the TRPM family.
Huang et al. (2020)
32 more