› 6bql

X-ray diffraction
2Å resolution

Crystal Structure of the Human CAMKK2B in complex with TAE-226

Released:
DOI: 10.2210/pdb6bql/pdb
PDB entry 6bql coloured by chain, front view.
PDB entry 6bql coloured by chain, side view.
PDB entry 6bql coloured by chain, top view.
Source organism: Homo sapiens
Entry authors: Counago RM, de Souza GP, dos Reis CV, Ramos PZ, Drewry D, Massirer KB, Arruda P, Edwards AM, Elkins JM, Structural Genomics Consortium (SGC)

Function and Biology Details

Reaction catalysed: 
ATP + a protein = ADP + a phosphoprotein
Biochemical function:
Biological process:
Cellular component:
  • not assigned
Sequence domains:

Structure analysis Details

Assemblies composition:
monomeric (preferred)
homo dimer
Assembly name:
PDBe Complex ID:
PDB-CPX-188735 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Calcium/calmodulin-dependent protein kinase kinase 2 Chain: A
Molecule details ›
Chain: A
Length: 291 amino acids
Theoretical weight: 33.13 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli BL21(DE3)
UniProt:
  • Canonical: Q96RR4 (Residues: 161-449; Coverage: 49%)
Gene names: CAMKK2, CAMKKB, KIAA0787
Sequence domains: Protein kinase domain

Ligands and Environments

5 bound ligands:
Ligand BI9 1 x BI9
Ligand EDO 1 x EDO
Ligand CL 1 x CL
Ligand ACT 2 x ACT
Ligand NH4 1 x NH4
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: APS BEAMLINE 24-ID-C
Spacegroup: P43212
Unit cell:
a: 73.738Å b: 73.738Å c: 123.883Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.189 0.187 0.225
Expression system: Escherichia coli BL21(DE3)

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