› 6brc

X-ray diffraction
2.2Å resolution

Crystal Structure of the Human CAMKK2B in complex with AP26113-analog (ALK-IN-1)

Released:
DOI: 10.2210/pdb6brc/pdb
PDB entry 6brc coloured by chain, front view.
PDB entry 6brc coloured by chain, side view.
PDB entry 6brc coloured by chain, top view.
Source organism: Homo sapiens
Entry authors: Counago RM, dos Reis CV, de Souza GP, Ramos PZ, Drewry D, Massirer KB, Arruda P, Edwards AM, Elkins JM, Structural Genomics Consortium (SGC)

Function and Biology Details

Reaction catalysed: 
ATP + a protein = ADP + a phosphoprotein
Biochemical function:
Biological process:
Cellular component:
  • not assigned
Sequence domains:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-188735 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Calcium/calmodulin-dependent protein kinase kinase 2 Chains: A, B
Molecule details ›
Chains: A, B
Length: 291 amino acids
Theoretical weight: 33.13 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: Q96RR4 (Residues: 161-449; Coverage: 49%)
Gene names: CAMKK2, CAMKKB, KIAA0787
Sequence domains: Protein kinase domain

Ligands and Environments

2 bound ligands:
Ligand E5J 2 x E5J
Ligand NA 1 x NA
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: DIAMOND BEAMLINE I24
Spacegroup: P1
Unit cell:
a: 54.8Å b: 54.861Å c: 56.633Å
α: 72.38° β: 78.35° γ: 89.74°
R-values:
R R work R free
0.216 0.213 0.265
Expression system: Escherichia coli

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