› 6bwj

X-ray diffraction
3.1Å resolution

Crystal structure of the TRPV2 ion channel in complex with RTx

Released:
DOI: 10.2210/pdb6bwj/pdb
PDB entry 6bwj coloured by chain, front view.
PDB entry 6bwj coloured by chain, side view.
PDB entry 6bwj coloured by chain, top view.
Source organism: Oryctolagus cuniculus
Primary publication:
Conformational plasticity in the selectivity filter of the TRPV2 ion channel.
Zubcevic L, Le S, Yang H, Lee SY
Nat Struct Mol Biol 25 405-415 (2018)
PMID: 29728656

Function and Biology Details

Biochemical function:
Biological process:
Cellular component:
Sequence domains:

Structure analysis Details

Assembly composition:
homo tetramer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-124210 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Ion transport domain-containing protein Chains: A, B
Molecule details ›
Chains: A, B
Length: 776 amino acids
Theoretical weight: 87.61 KDa
Source organism: Oryctolagus cuniculus
Expression system: Spodoptera frugiperda
UniProt:
  • Canonical: G1SNM3 (Residues: 57-817; Coverage: 93%)
Gene name: TRPV2
Sequence domains:

Ligands and Environments

2 bound ligands:
Ligand 6EU 2 x 6EU
Ligand CA 2 x CA
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: APS BEAMLINE 22-ID
Unit cell:
a: 90.054Å b: 121.226Å c: 185.557Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.249 0.247 0.272
Expression system: Spodoptera frugiperda

Quick links

Citations

5 review citations

Transient Receptor Potential Channels and Calcium Signaling.
Vangeel et al. (2019)
4 more

15 mentions without citation

Structural insights into the gating mechanisms of TRPV channels.
Pumroy et al. (2020)
14 more