› 6bxi

X-ray diffraction
2.2Å resolution

X-ray crystal structure of NDR1 kinase domain

Released:
DOI: 10.2210/pdb6bxi/pdb
PDB entry 6bxi coloured by chain, front view.
PDB entry 6bxi coloured by chain, side view.
PDB entry 6bxi coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
Structural Basis for Auto-Inhibition of the NDR1 Kinase Domain by an Atypically Long Activation Segment.
Xiong S, Lorenzen K, Couzens AL, Templeton CM, Rajendran D, Mao DYL, Juang YC, Chiovitti D, Kurinov I, Guettler S, Gingras AC, Sicheri F
Structure 26 1101-1115.e6 (2018)
PMID: 29983373

Function and Biology Details

Reaction catalysed: 
ATP + a protein = ADP + a phosphoprotein
Biochemical function:
Biological process:
Cellular component:
  • not assigned
Sequence domains:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-172231 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Serine/threonine-protein kinase 38 Chains: A, B
Molecule details ›
Chains: A, B
Length: 333 amino acids
Theoretical weight: 38.75 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: Q15208 (Residues: 82-414; Coverage: 72%)
Gene names: NDR1, STK38
Sequence domains: Protein kinase domain

Ligands and Environments

2 bound ligands:
Ligand ANP 2 x ANP
Ligand MG 2 x MG
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: APS BEAMLINE 24-ID-C
Spacegroup: C2
Unit cell:
a: 117.191Å b: 117.967Å c: 95.044Å
α: 90° β: 124.88° γ: 90°
R-values:
R R work R free
0.173 0.17 0.212
Expression system: Escherichia coli

Quick links

Citations

4 review citations

A census of pathway maps in cancer systems biology.
Kuenzi et al. (2020)
3 more

5 mentions without citation

Lighting the way: Recent insights into the structure and regulation of phototropin blue light receptors.
Hart et al. (2021)
4 more