Function and Biology Details
Reaction catalysed:
(1a) a [histone H3]-N(6),N(6)-dimethyl-L-lysine(36) + 2-oxoglutarate + O(2) = a [histone H3]-N(6)-methyl-L-lysine(36) + succinate + formaldehyde + CO(2)
Biochemical function:
Biological process:
Cellular component:
Structure analysis Details
Assembly composition:
hetero trimer (preferred)
PDBe Complex ID:
PDB-CPX-143263 (preferred)
Entry contents:
3 distinct polypeptide molecules
Macromolecules (3 distinct):
S-phase kinase-associated protein 1
Molecule details ›
Lysine-specific demethylase 2A
Molecule details ›
Chains: E, F, I
Length: 47 amino acids
Theoretical weight: 5.95 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
Sequence domains: F-box domain
Length: 47 amino acids
Theoretical weight: 5.95 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
- Canonical:
Q9Y2K7 (Residues: 888-932; Coverage: 4%)
Sequence domains: F-box domain
Ubiquitin
Molecule details ›
Chains: C, D, H
Length: 87 amino acids
Theoretical weight: 9.99 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
Sequence domains: Ubiquitin family
Length: 87 amino acids
Theoretical weight: 9.99 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
- Canonical: P0CG47 (Residues: 152-163, 164-228; Coverage: 34%)
Sequence domains: Ubiquitin family
Ligands and Environments
No bound ligands
No modified residues
Experiments and Validation Details
X-ray source:
RIGAKU FR-E DW
Spacegroup:
P212121
Expression system: Escherichia coli
