› 6c10

X-ray diffraction
1.4Å resolution

Crystal structure of mouse PCDH15 EC11-EL

Released:
DOI: 10.2210/pdb6c10/pdb
Model geometry
Fit model/data
PDB entry 6c10 coloured by chain, front view.
PDB entry 6c10 coloured by chain, side view.
PDB entry 6c10 coloured by chain, top view.
Source organism: Mus musculus
Primary publication:
Structure of mouse protocadherin 15 of the stereocilia tip link in complex with LHFPL5.
Ge J, Elferich J, Goehring A, Zhao H, Schuck P, Gouaux E
OpenAccess logo Elife 7 (2018)
PMID: 30070639

Function and Biology Details

Biochemical function:
Biological process:
Cellular component:
Sequence domains:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-189381 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Protocadherin-15 Chain: A
Molecule details ›
Chain: A
Length: 247 amino acids
Theoretical weight: 27.91 KDa
Source organism: Mus musculus
Expression system: Homo sapiens
UniProt:
  • Canonical: Q99PJ1 (Residues: 1144-1381; Coverage: 12%)
Gene name: Pcdh15
Sequence domains: Cadherin domain

Ligands and Environments

1 bound ligand:
Ligand MAN 1 x MAN
No modified residues

Experiments and Validation Details

wwPDB Validation report is not available for this entry.
X-ray source: APS BEAMLINE 24-ID-C
Spacegroup: P43212
Unit cell:
a: 57.68Å b: 57.68Å c: 159.18Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.171 0.169 0.195
Expression system: Homo sapiens

Quick links

Citations

13 review citations

Discoveries in structure and physiology of mechanically activated ion channels.
Kefauver et al. (2020)
12 more

5 mentions without citation

ADAM12 and alpha9beta1 integrin are instrumental in human myogenic cell differentiation.
Lafuste et al. (2005)
4 more