› 6c1e

X-ray diffraction
2.86Å resolution

NavAb NormoPP mutant

Released:
DOI: 10.2210/pdb6c1e/pdb
PDB entry 6c1e coloured by chain, front view.
PDB entry 6c1e coloured by chain, side view.
PDB entry 6c1e coloured by chain, top view.
Source organism: Aliarcobacter butzleri RM4018
Primary publication:
Structural basis for gating pore current in periodic paralysis.
Jiang D, Gamal El-Din TM, Ing C, Lu P, Pomès R, Zheng N, Catterall WA
Nature 557 590-594 (2018)
PMID: 29769724

Function and Biology Details

Biochemical function:
Biological process:
Cellular component:
Sequence domains:

Structure analysis Details

Assembly composition:
homo tetramer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-108631 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Ion transport domain-containing protein Chains: A, B
Molecule details ›
Chains: A, B
Length: 285 amino acids
Theoretical weight: 33 KDa
Source organism: Aliarcobacter butzleri RM4018
Expression system: Trichoplusia ni
UniProt:
  • Canonical: A8EVM5 (Residues: 1-267; Coverage: 100%)
Gene name: Abu_1752
Sequence domains: Ion transport protein

Ligands and Environments

3 bound ligands:
Ligand PX4 18 x PX4
Ligand BNC 1 x BNC
Ligand UHH 1 x UHH
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: ALS BEAMLINE 8.2.1
Spacegroup: I222
Unit cell:
a: 126.775Å b: 126.997Å c: 192.287Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.214 0.212 0.24
Expression system: Trichoplusia ni

Quick links

Citations

12 review citations

Emerging Diversity in Lipid-Protein Interactions.
Corradi et al. (2019)
11 more

3 mentions without citation

Recent advances in our understanding of the structure and function of more unusual cation channels.
Brown et al. (2019)
2 more