› 6c4s

X-ray diffraction
1.5Å resolution

Human cSrc SH3 Domain in complex with Choline Kinase fragment 60-69

Released:
DOI: 10.2210/pdb6c4s/pdb
PDB entry 6c4s coloured by chain, front view.
PDB entry 6c4s coloured by chain, side view.
PDB entry 6c4s coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
Molecular basis for the interaction between human choline kinase alpha and the SH3 domain of the c-Src tyrosine kinase.
Kall SL, Whitlatch K, Smithgall TE, Lavie A
Sci Rep 9 17121 (2019)
PMID: 31745227

Function and Biology Details

Reaction catalysed: 
ATP + a [protein]-L-tyrosine = ADP + a [protein]-L-tyrosine phosphate
Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
  • not assigned
Sequence domains:

Structure analysis Details

Assembly composition:
homo dimer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-146388 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Proto-oncogene tyrosine-protein kinase Src Chains: A, B
Molecule details ›
Chains: A, B
Length: 74 amino acids
Theoretical weight: 8.17 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: P12931 (Residues: 87-144; Coverage: 11%)
Gene names: SRC, SRC1
Sequence domains: SH3 domain
Structure domains: SH3 Domains

Ligands and Environments

1 bound ligand:
Ligand ZN 2 x ZN
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: APS BEAMLINE 21-ID-F
Spacegroup: P21
Unit cell:
a: 31.117Å b: 38.753Å c: 57.966Å
α: 90° β: 95.7° γ: 90°
R-values:
R R work R free
0.189 0.187 0.226
Expression system: Escherichia coli

Quick links

Citations

2 review citations

Choline Kinase: An Unexpected Journey for a Precision Medicine Strategy in Human Diseases.
Lacal et al. (2021)
1 more

1 mention without citation

Molecular basis for the interaction between human choline kinase alpha and the SH3 domain of the c-Src tyrosine kinase.
Kall et al. (2019)