› 6c8u

Solution NMR

Solution structure of Musashi2 RRM1

Released:
DOI: 10.2210/pdb6c8u/pdb
PDB entry 6c8u coloured by chain, ensemble of 10 models, front view.
PDB entry 6c8u coloured by chain, ensemble of 10 models, side view.
PDB entry 6c8u coloured by chain, ensemble of 10 models, top view.
Source organism: Homo sapiens
Primary publication:
Crystal and solution structures of human oncoprotein Musashi-2 N-terminal RNA recognition motif 1.
Lan L, Xing M, Kashipathy M, Douglas J, Gao P, Battaile K, Hanzlik R, Lovell S, Xu L
Proteins 88 573-583 (2020)
PMID: 31603583

Function and Biology Details

Biochemical function:
Biological process:
  • not assigned
Cellular component:
  • not assigned
Sequence domains:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-188437 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
RNA-binding protein Musashi homolog 2 Chain: 1
Molecule details ›
Chain: 1
Length: 115 amino acids
Theoretical weight: 13.15 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: Q96DH6 (Residues: 21-111; Coverage: 28%)
Gene name: MSI2
Sequence domains: RNA recognition motif

Ligands and Environments

No bound ligands
No modified residues

Experiments and Validation Details

Entry percentile scores
Refinement method: simulated annealing
Expression system: Escherichia coli

Quick links

Citations

3 review citations

RNA-Targeted Therapies and High-Throughput Screening Methods.
Zhu et al. (2020)
2 more

3 mentions without citation

Identification and Validation of an Aspergillus nidulans Secondary Metabolite Derivative as an Inhibitor of the Musashi-RNA Interaction.
Lan et al. (2020)
2 more