› 6ccf

X-ray diffraction
2.1Å resolution

Crystal Structure of the Human CAMKK1A in complex with Hesperadin

Released:
DOI: 10.2210/pdb6ccf/pdb
PDB entry 6ccf coloured by chain, front view.
PDB entry 6ccf coloured by chain, side view.
PDB entry 6ccf coloured by chain, top view.
Source organism: Homo sapiens
Entry authors: Santiago AS, Counago RM, dos Reis CV, Ramos PZ, Silva PNB, Drewry D, Elkins JM, Massirer KB, Arruda P, Edwards AM, Structural Genomics Consortium (SGC)

Function and Biology Details

Reaction catalysed: 
ATP + a protein = ADP + a phosphoprotein
Biochemical function:
Biological process:
Cellular component:
  • not assigned
Sequence domains:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-185406 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Calcium/calmodulin-dependent protein kinase kinase 1 Chains: A, B
Molecule details ›
Chains: A, B
Length: 290 amino acids
Theoretical weight: 32.7 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli BL21(DE3)
UniProt:
  • Canonical: Q8N5S9 (Residues: 124-411; Coverage: 57%)
Gene names: CAMKK1, CAMKKA
Sequence domains: Protein kinase domain

Ligands and Environments

3 bound ligands:
Ligand H1N 2 x H1N
Ligand SCN 1 x SCN
Ligand EDO 1 x EDO
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: APS BEAMLINE 24-ID-E
Spacegroup: P21
Unit cell:
a: 49.215Å b: 83.174Å c: 80.124Å
α: 90° β: 97.27° γ: 90°
R-values:
R R work R free
0.212 0.21 0.244
Expression system: Escherichia coli BL21(DE3)

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