Function and Biology Details
Reactions catalysed:
NAD(+) + (ADP-D-ribosyl)(n)-acceptor = nicotinamide + (ADP-D-ribosyl)(n+1)-acceptor
S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine
Biochemical function:
- not assigned
Biological process:
- not assigned
Cellular component:
- not assigned
Sequence domains:
Structure analysis Details
Assembly composition:
hetero tetramer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-180151 (preferred)
Entry contents:
2 distinct polypeptide molecules
Macromolecules (2 distinct):
Poly [ADP-ribose] polymerase tankyrase-1
Molecule details ›
Chains: A, B
Length: 348 amino acids
Theoretical weight: 37.9 KDa
Source organism: Mus musculus
Expression system: Escherichia coli BL21
UniProt:
Sequence domains: Ankyrin repeats (3 copies)
Length: 348 amino acids
Theoretical weight: 37.9 KDa
Source organism: Mus musculus
Expression system: Escherichia coli BL21
UniProt:
- Canonical:
Q6PFX9 (Residues: 308-655; Coverage: 26%)
Sequence domains: Ankyrin repeats (3 copies)
E3 ubiquitin-protein ligase RNF146
Molecule details ›
Chains: C, D
Length: 13 amino acids
Theoretical weight: 1.29 KDa
Source organism: Homo sapiens
Expression system: Not provided
UniProt:
Length: 13 amino acids
Theoretical weight: 1.29 KDa
Source organism: Homo sapiens
Expression system: Not provided
UniProt:
- Canonical: Q9NTX7 (Residues: 191-203; Coverage: 4%)
Ligands and Environments
No bound ligands
No modified residues
Experiments and Validation Details
X-ray source:
ALS BEAMLINE 8.2.2
Spacegroup:
C2
Expression systems:
- Escherichia coli BL21
- Not provided
