6cht

X-ray diffraction
3.17Å resolution

HNF4alpha in complex with the corepressor EBP1 fragment

Released:

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
  • not assigned

Structure analysis Details

Assembly composition:
hetero decamer (preferred)
PDBe Complex ID:
PDB-CPX-154352 (preferred)
Entry contents:
2 distinct polypeptide molecules
Macromolecules (2 distinct):
Hepatocyte nuclear factor 4-alpha Chains: A, B, D, E, G, H, J, K, M, N, P, Q, S, T, V, W
Molecule details ›
Chains: A, B, D, E, G, H, J, K, M, N, P, Q, S, T, V, W
Length: 245 amino acids
Theoretical weight: 27.54 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: P41235 (Residues: 148-391; Coverage: 52%)
Gene names: HNF4, HNF4A, NR2A1, TCF14
Sequence domains: Ligand-binding domain of nuclear hormone receptor
Structure domains: Retinoid X Receptor
Proliferation-associated protein 2G4 Chains: C, F, I, L
Molecule details ›
Chains: C, F, I, L
Length: 20 amino acids
Theoretical weight: 2.21 KDa
Source organism: Homo sapiens
Expression system: Not provided
UniProt:
  • Canonical: Q9UQ80 (Residues: 349-368; Coverage: 5%)
Gene names: EBP1, PA2G4

Ligands and Environments

1 bound ligand:
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: APS BEAMLINE 22-ID
Spacegroup: P21
Unit cell:
a: 139.721Å b: 104.946Å c: 139.563Å
α: 90° β: 90.61° γ: 90°
R-values:
R R work R free
0.414 0.262 0.274
Expression systems:
  • Escherichia coli
  • Not provided