› 6cjs

X-ray diffraction
1.9Å resolution

Candida albicans Hsp90 nucleotide binding domain in complex with AUY922

Released:
DOI: 10.2210/pdb6cjs/pdb
Model geometry
Fit model/data
PDB entry 6cjs coloured by chain, front view.
PDB entry 6cjs coloured by chain, side view.
PDB entry 6cjs coloured by chain, top view.
Source organism: Candida albicans SC5314
Primary publication:
Structural basis for species-selective targeting of Hsp90 in a pathogenic fungus.
Whitesell L, Robbins N, Huang DS, McLellan CA, Shekhar-Guturja T, LeBlanc EV, Nation CS, Hui R, Hutchinson A, Collins C, Chatterjee S, Trilles R, Xie JL, Krysan DJ, Lindquist S, Porco JA, Tatu U, Brown LE, Pizarro J, Cowen LE
OpenAccess logo Nat Commun 10 402 (2019)
PMID: 30679438

Function and Biology Details

Biochemical function:
Biological process:
Cellular component:
  • not assigned
Sequence domains:

Structure analysis Details

Assembly composition:
homo dimer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-155490 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Heat shock protein 90 homolog Chain: A
Molecule details ›
Chain: A
Length: 230 amino acids
Theoretical weight: 26.21 KDa
Source organism: Candida albicans SC5314
Expression system: Escherichia coli
UniProt:
  • Canonical: P46598 (Residues: 7-218; Coverage: 30%)
Gene names: CAALFM_C702030WA, CaJ7.0234, CaO19.13868, CaO19.6515, HSP90
Sequence domains: Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase
Structure domains: Histidine kinase-like ATPase, C-terminal domain

Ligands and Environments

2 bound ligands:
Ligand 2GJ 1 x 2GJ
Ligand EDO 1 x EDO
No modified residues

Experiments and Validation Details

wwPDB Validation report is not available for this entry.
X-ray source: APS BEAMLINE 23-ID-D
Spacegroup: I4122
Unit cell:
a: 86.21Å b: 86.21Å c: 225.846Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.167 0.167 0.193
Expression system: Escherichia coli

Quick links

Citations

21 review citations

Antifungal Drug Resistance: Molecular Mechanisms in Candida albicans and Beyond.
Lee et al. (2021)
20 more

2 mentions without citation

Effects of Hsp90 Inhibitor Ganetespib on Inhibition of Azole-Resistant Candida albicans.
Yuan et al. (2021)
1 more