› 6coy

Electron Microscopy
3.36Å resolution

Human CLC-1 chloride ion channel, transmembrane domain

Released:
DOI: 10.2210/pdb6coy/pdb
PDB entry 6coy coloured by chain, front view.
PDB entry 6coy coloured by chain, side view.
PDB entry 6coy coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
Structure of the CLC-1 chloride channel from Homo sapiens.
Park E, MacKinnon R
Elife 7 (2018)
PMID: 29809153
Related structures: EMD-7544

Function and Biology Details

Biochemical function:
Biological process:
Cellular component:
Sequence domains:

Structure analysis Details

Assembly composition:
homo dimer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-152936 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Chloride channel protein 1 Chains: A, B
Molecule details ›
Chains: A, B
Length: 988 amino acids
Theoretical weight: 108.73 KDa
Source organism: Homo sapiens
Expression system: Homo sapiens
UniProt:
  • Canonical: P35523 (Residues: 1-988; Coverage: 100%)
Gene names: CLC1, CLCN1
Sequence domains: Voltage gated chloride channel

Ligands and Environments

1 bound ligand:
Ligand CL 4 x CL
No modified residues

Experiments and Validation Details

Entry percentile scores
Resolution: 3.36Å
Relevant EMDB volumes: EMD-7544
Expression system: Homo sapiens

Quick links

Citations

11 review citations

Frontiers in Cryo Electron Microscopy of Complex Macromolecular Assemblies.
Ognjenović et al. (2019)
10 more

13 mentions without citation

The Role of Chloride Channels in Plant Responses to NaCl.
Liu et al. (2023)
12 more