› 6cp5

Electron Microscopy
4.2Å resolution

Monomer yeast ATP synthase Fo reconstituted in nanodisc with inhibitor of oligomycin bound generated from focused refinement.

Released:
DOI: 10.2210/pdb6cp5/pdb
PDB entry 6cp5 coloured by chain, front view.
PDB entry 6cp5 coloured by chain, side view.
PDB entry 6cp5 coloured by chain, top view.
Source organism: Saccharomyces cerevisiae S288C
Primary publication:
High-resolution cryo-EM analysis of the yeast ATP synthase in a lipid membrane.
Srivastava AP, Luo M, Zhou W, Symersky J, Bai D, Chambers MG, Faraldo-Gómez JD, Liao M, Mueller DM
Science 360 (2018)
PMID: 29650704
Related structures: EMD-7547

Function and Biology Details

Biochemical function:
Biological process:
Cellular component:
Sequence domains:

Structure analysis Details

Assembly composition:
hetero hexadecamer (preferred)
PDBe Complex ID:
PDB-CPX-133641 (preferred)
Entry contents:
7 distinct polypeptide molecules
Macromolecules (7 distinct):
ATP synthase subunit 9, mitochondrial Chains: K, L, M, N, O, P, Q, R, S, T
Molecule details ›
Chains: K, L, M, N, O, P, Q, R, S, T
Length: 76 amino acids
Theoretical weight: 7.79 KDa
Source organism: Saccharomyces cerevisiae S288C
UniProt:
  • Canonical: P61829 (Residues: 1-76; Coverage: 100%)
Gene names: ATP9, OLI1, OLI3, PHO2, Q0130
Sequence domains: ATP synthase subunit C
ATP synthase protein 8 Chain: 8
Molecule details ›
Chain: 8
Length: 48 amino acids
Theoretical weight: 5.83 KDa
Source organism: Saccharomyces cerevisiae S288C
UniProt:
  • Canonical: P00856 (Residues: 1-48; Coverage: 100%)
Gene names: AAP1, ATP8, Q0080
Sequence domains: Fungal ATP synthase protein 8 (A6L)
ATP synthase subunit a Chain: X
Molecule details ›
Chain: X
Length: 249 amino acids
Theoretical weight: 27.9 KDa
Source organism: Saccharomyces cerevisiae S288C
UniProt:
  • Canonical: P00854 (Residues: 11-259; Coverage: 96%)
Gene names: ATP6, OLI2, OLI4, PHO1, Q0085
Sequence domains: ATP synthase A chain
ATP synthase subunit 4, mitochondrial Chain: Z
Molecule details ›
Chain: Z
Length: 209 amino acids
Theoretical weight: 23.19 KDa
Source organism: Saccharomyces cerevisiae S288C
UniProt:
  • Canonical: P05626 (Residues: 36-244; Coverage: 86%)
Gene names: ATP4, LPF7C, YPL078C
Sequence domains: Mitochondrial ATP synthase B chain precursor (ATP-synt_B)
ATP synthase subunit d, mitochondrial Chain: 7
Molecule details ›
Chain: 7
Length: 173 amino acids
Theoretical weight: 19.71 KDa
Source organism: Saccharomyces cerevisiae S288C
UniProt:
  • Canonical: P30902 (Residues: 2-174; Coverage: 99%)
Gene names: ATP7, YKL016C
Sequence domains: ATP synthase D chain, mitochondrial (ATP5H)
ATP synthase subunit f, mitochondrial Chain: U
Molecule details ›
Chain: U
Length: 95 amino acids
Theoretical weight: 10.58 KDa
Source organism: Saccharomyces cerevisiae S288C
UniProt:
  • Canonical: Q06405 (Residues: 7-101; Coverage: 94%)
Gene names: ATP17, D9481.21, YDR377W
Sequence domains: Mitochondrial F1-F0 ATP synthase subunit F of fungi
ATP synthase subunit J, mitochondrial Chain: J
Molecule details ›
Chain: J
Length: 37 amino acids
Theoretical weight: 4.15 KDa
Source organism: Saccharomyces cerevisiae S288C
UniProt:
  • Canonical: P81450 (Residues: 1-37; Coverage: 63%)
Gene names: ATP18, YML081BC, YML081C-A
Sequence domains: ATP synthase j chain

Ligands and Environments

1 bound ligand:
Ligand EFO 4 x EFO
1 modified residue:
Ligand FME 10 x FME

Experiments and Validation Details

Entry percentile scores
Resolution: 4.2Å
Relevant EMDB volumes: EMD-7547

Quick links

Citations

32 review citations

The mitochondrial permeability transition: Recent progress and open questions.
Bernardi et al. (2022)
31 more

3 mentions without citation

High-resolution cryo-EM analysis of the yeast ATP synthase in a lipid membrane.
Srivastava et al. (2018)
2 more