Function and Biology Details
Reaction catalysed:
GTP + H2O = GDP + phosphate + H(+).
Biochemical function:
Biological process:
Cellular component:
Sequence domains:
- Small GTPase superfamily, ARF/SAR type
- Clathrin adaptor, mu subunit
- HIV-1 Nef protein, core domain superfamily
- HIV negative factor Nef
- P-loop containing nucleoside triphosphate hydrolase
- Adaptor protein complex, sigma subunit
- HIV-1 Nef protein, anchor domain superfamily
- Mu homology domain
17 more domains
Structure analysis Details
Assembly composition:
hetero 24-mer (preferred)
PDBe Complex ID:
PDB-CPX-136953 (preferred)
Entry contents:
6 distinct polypeptide molecules
Macromolecules (6 distinct):
Bone marrow stromal antigen 2; Protein Nef
Molecule details ›
Chains: N, T, Y, Z, c, d
Length: 264 amino acids
Theoretical weight: 29.96 KDa
Source organisms: Expression system: Escherichia coli
UniProt:
Sequence domains: Negative factor, (F-Protein) or Nef
Length: 264 amino acids
Theoretical weight: 29.96 KDa
Source organisms: Expression system: Escherichia coli
UniProt:
- Canonical:
Q10589 (Residues: 2-21, 60-60; Coverage: 12%) - Canonical: P03404 (Residues: 1-32, 34-206; Coverage: 100%)
Sequence domains: Negative factor, (F-Protein) or Nef
AP-1 complex subunit beta-1
Molecule details ›
Chains: B, I, J
Length: 570 amino acids
Theoretical weight: 64.46 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
Sequence domains: Adaptin N terminal region
Length: 570 amino acids
Theoretical weight: 64.46 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
- Canonical: Q10567 (Residues: 14-583; Coverage: 60%)
Sequence domains: Adaptin N terminal region
ADP-ribosylation factor 1
AP-1 complex subunit gamma-1
AP-1 complex subunit mu-1
AP-1 complex subunit sigma-3
