› 6cvz

X-ray diffraction
1.8Å resolution

Function and Biology Details

Reaction catalysed: 
S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine
Biochemical function:
Biological process:
Cellular component:
Sequence domains:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-180141 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
E3 ubiquitin-protein ligase RFWD3 Chains: A, B, C
Molecule details ›
Chains: A, B, C
Length: 351 amino acids
Theoretical weight: 38.8 KDa
Source organism: Homo sapiens
Expression system: Spodoptera frugiperda
UniProt:
  • Canonical: Q6PCD5 (Residues: 425-774; Coverage: 45%)
Gene names: RFWD3, RNF201

Ligands and Environments

1 bound ligand:
Ligand MG 3 x MG
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: APS BEAMLINE 24-ID-E
Spacegroup: P32
Unit cell:
a: 91.991Å b: 91.991Å c: 110.738Å
α: 90° β: 90° γ: 120°
R-values:
R R work R free
0.215 0.214 0.239
Expression system: Spodoptera frugiperda

Quick links

Citations

8 citation in other articles

Critical assessment of methods of protein structure prediction (CASP)-Round XIII.
Kryshtafovych et al. (2019)
7 more

3 mentions without citation

Fanconi anemia pathway as a prospective target for cancer intervention.
Liu et al. (2020)
2 more