Function and Biology Details
Biochemical function:
Biological process:
Cellular component:
Sequence domains:
- Ubiquitin/SUMO-activating enzyme E1-like
- THIF-type NAD/FAD binding fold
- ThiF/MoeB/HesA family
- Ubiquitin-activating enzyme
- SUMO-activating enzyme subunit 2, C-terminal domain
- Ubiquitin/SUMO-activating enzyme ubiquitin-like domain
- Ubiquitin-activating enzyme E1, conserved site
- Ubiquitin-activating enzyme E1, Cys active site
4 more domains
Structure analysis Details
Assembly composition:
hetero dimer (preferred)
Assembly name:
SUMO activating enzyme complex, SAE1-UBA2 (preferred)
PDBe Complex ID:
PDB-CPX-193648 (preferred)
Entry contents:
2 distinct polypeptide molecules
Macromolecules (2 distinct):
SUMO-activating enzyme subunit 1
Molecule details ›
Chain: C
Length: 346 amino acids
Theoretical weight: 38.5 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
Sequence domains: ThiF family
Structure domains: NAD(P)-binding Rossmann-like Domain
Length: 346 amino acids
Theoretical weight: 38.5 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
- Canonical:
Q9UBE0 (Residues: 1-346; Coverage: 100%)
Sequence domains: ThiF family
Structure domains: NAD(P)-binding Rossmann-like Domain
SUMO-activating enzyme subunit 2
Molecule details ›
Chain: D
Length: 660 amino acids
Theoretical weight: 73.49 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
Sequence domains:
Length: 660 amino acids
Theoretical weight: 73.49 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
- Canonical: Q9UBT2 (Residues: 1-640; Coverage: 100%)
Sequence domains:
