› 6cxi

Electron Microscopy
11Å resolution

Cardiac thin filament decorated with C0C1 fragment of cardiac myosin binding protein C mode 1

Released:
DOI: 10.2210/pdb6cxi/pdb
PDB entry 6cxi coloured by chain, front view.
PDB entry 6cxi coloured by chain, side view.
PDB entry 6cxi coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
N-Terminal Domains of Cardiac Myosin Binding Protein C Cooperatively Activate the Thin Filament.
Risi C, Belknap B, Forgacs-Lonart E, Harris SP, Schröder GF, White HD, Galkin VE
Structure 26 1604-1611.e4 (2018)
PMID: 30270174
Related structures: EMD-7780

Function and Biology Details

Biochemical function:
Biological process:
Cellular component:
Sequence domains:

Structure analysis Details

Assembly composition:
hetero icosamer (preferred)
PDBe Complex ID:
PDB-CPX-159069 (preferred)
Entry contents:
4 distinct polypeptide molecules
Macromolecules (4 distinct):
Actin, cytoplasmic 2 Chains: A, B, C, D, E
Molecule details ›
Chains: A, B, C, D, E
Length: 375 amino acids
Theoretical weight: 41.84 KDa
Source organism: Homo sapiens
Expression system: Homo sapiens
UniProt:
  • Canonical: P63261 (Residues: 1-375; Coverage: 100%)
Gene names: ACTG, ACTG1
Sequence domains: Actin
Myosin-binding protein C, cardiac-type Chains: G, H, I, J, K, L
Molecule details ›
Chains: G, H, I, J, K, L
Length: 109 amino acids
Theoretical weight: 12.18 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: Q14896 (Residues: 151-258; Coverage: 9%)
Gene name: MYBPC3
Sequence domains: Immunoglobulin I-set domain
Myosin-binding protein C, cardiac-type Chains: M, N, O, P, Q
Molecule details ›
Chains: M, N, O, P, Q
Length: 101 amino acids
Theoretical weight: 10.71 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: Q14896 (Residues: 1-101; Coverage: 8%)
Gene name: MYBPC3
Sequence domains: Immunoglobulin I-set domain
Tropomyosin Chains: S, T, U, V
Molecule details ›
Chains: S, T, U, V
Length: 127 amino acids
Theoretical weight: 10.83 KDa
Source organism: Homo sapiens
Expression system: Homo sapiens

Ligands and Environments

No bound ligands
No modified residues

Experiments and Validation Details

Entry percentile scores
Resolution: 11Å
Relevant EMDB volumes: EMD-7780
Expression systems:
  • Homo sapiens
  • Escherichia coli

Quick links

Citations

6 review citations

MyBP-C: one protein to govern them all.
Heling et al. (2020)
5 more

5 mentions without citation

N-Terminal Domains of Cardiac Myosin Binding Protein C Cooperatively Activate the Thin Filament.
Risi et al. (2018)
4 more