› 6d0s

X-ray diffraction
2.3Å resolution

RabGAP domain of human TBC1D22B

Released:
DOI: 10.2210/pdb6d0s/pdb
PDB entry 6d0s coloured by chain, front view.
PDB entry 6d0s coloured by chain, side view.
PDB entry 6d0s coloured by chain, top view.
Source organism: Homo sapiens
Entry authors: Tong Y, Tempel W, Arrowsmith CH, Edwards AM, Bountra C, Park H, Structural Genomics Consortium (SGC)

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
  • not assigned
Sequence domains:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-192612 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
TBC1 domain family member 22B Chain: A
Molecule details ›
Chain: A
Length: 346 amino acids
Theoretical weight: 41.77 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli BL21(DE3)
UniProt:
  • Canonical: Q9NU19 (Residues: 178-505; Coverage: 65%)
Gene names: C6orf197, TBC1D22B
Sequence domains: Rab-GTPase-TBC domain
Structure domains: Ypt/Rab-GAP domain of gyp1p, domain 3

Ligands and Environments

2 bound ligands:
Ligand SO4 1 x SO4
Ligand UNX 10 x UNX
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: APS BEAMLINE 23-ID-D
Spacegroup: P6522
Unit cell:
a: 78.015Å b: 78.015Å c: 217.699Å
α: 90° β: 90° γ: 120°
R-values:
R R work R free
0.199 0.197 0.239
Expression system: Escherichia coli BL21(DE3)

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