› 6d4a

X-ray diffraction
1.75Å resolution

Cell Surface Receptor with Bound Ligand at 1.75-A Resolution

Released:
DOI: 10.2210/pdb6d4a/pdb
PDB entry 6d4a coloured by chain, front view.
PDB entry 6d4a coloured by chain, side view.
PDB entry 6d4a coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
Small Molecule Binding to Alzheimer Risk Factor CD33 Promotes Aβ Phagocytosis.
Miles LA, Hermans SJ, Crespi GAN, Gooi JH, Doughty L, Nero TL, Markulić J, Ebneth A, Wroblowski B, Oehlrich D, Trabanco AA, Rives ML, Royaux I, Hancock NC, Parker MW
iScience 19 110-118 (2019)
PMID: 31369984

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
  • not assigned
Sequence domains:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-148857 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Myeloid cell surface antigen CD33 Chains: A, B
Molecule details ›
Chains: A, B
Length: 127 amino acids
Theoretical weight: 14.65 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: P20138 (Residues: 18-143; Coverage: 36%)
Gene names: CD33, SIGLEC3
Sequence domains: Immunoglobulin V-set domain
Structure domains: Immunoglobulins

Ligands and Environments

2 bound ligands:
Ligand GOL 3 x GOL
Ligand FVP 2 x FVP
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: AUSTRALIAN SYNCHROTRON BEAMLINE MX1
Spacegroup: P21
Unit cell:
a: 29.391Å b: 68.339Å c: 73.618Å
α: 90° β: 97.45° γ: 90°
R-values:
R R work R free
0.178 0.176 0.202
Expression system: Escherichia coli

Quick links

Citations

17 review citations

The Role of Microglia and the Nlrp3 Inflammasome in Alzheimer's Disease.
Hanslik et al. (2020)
16 more

3 mentions without citation

Sialic Acids and Their Influence on Human NK Cell Function.
Rosenstock et al. (2021)
2 more