› 6d73

Electron Microscopy
3.8Å resolution

Cryo-EM structure of the zebrafish TRPM2 channel in the presence of Ca2+

Released:
DOI: 10.2210/pdb6d73/pdb
PDB entry 6d73 coloured by chain, front view.
PDB entry 6d73 coloured by chain, side view.
PDB entry 6d73 coloured by chain, top view.
Source organism: Danio rerio
Primary publication:
Visualizing structural transitions of ligand-dependent gating of the TRPM2 channel.
Yin Y, Wu M, Hsu AL, Borschel WF, Borgnia MJ, Lander GC, Lee SY
Nat Commun 10 3740 (2019)
PMID: 31431622
Related structures: EMD-7822

Function and Biology Details

Biochemical function:
Biological process:
Cellular component:
Sequence domains:

Structure analysis Details

Assembly composition:
homo tetramer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-166576 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Transient receptor potential cation channel, subfamily M Chains: A, B, C, D
Molecule details ›
Chains: A, B, C, D
Length: 1466 amino acids
Theoretical weight: 167.61 KDa
Source organism: Danio rerio
Expression system: Homo sapiens

Ligands and Environments

1 bound ligand:
Ligand CA 4 x CA
No modified residues

Experiments and Validation Details

Entry percentile scores
Resolution: 3.8Å
Relevant EMDB volumes: EMD-7822
Expression system: Homo sapiens

Quick links

Citations

7 review citations

Current View of Ligand and Lipid Recognition by the Menthol Receptor TRPM8.
Yin et al. (2020)
6 more

6 mentions without citation

A structural overview of the ion channels of the TRPM family.
Huang et al. (2020)
5 more