› 6dew

X-ray diffraction
2Å resolution

Structure of human COQ9 protein with bound isoprene.

Released:
DOI: 10.2210/pdb6dew/pdb
PDB entry 6dew coloured by chain, front view.
PDB entry 6dew coloured by chain, side view.
PDB entry 6dew coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
An Isoprene Lipid-Binding Protein Promotes Eukaryotic Coenzyme Q Biosynthesis.
Lohman DC, Aydin D, Von Bank HC, Smith RW, Linke V, Weisenhorn E, McDevitt MT, Hutchins P, Wilkerson EM, Wancewicz B, Russell J, Stefely MS, Beebe ET, Jochem A, Coon JJ, Bingman CA, Dal Peraro M, Pagliarini DJ
Mol Cell 73 763-774.e10 (2019)
PMID: 30661980

Function and Biology Details

Biochemical function:
Biological process:
Cellular component:
  • not assigned
Sequence domains:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-130882 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Ubiquinone biosynthesis protein COQ9, mitochondrial Chains: A, B, C, D, E, F
Molecule details ›
Chains: A, B, C, D, E, F
Length: 212 amino acids
Theoretical weight: 24.28 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: O75208 (Residues: 79-287; Coverage: 66%)
Gene names: C16orf49, COQ9, HSPC326, PSEC0129
Sequence domains:

Ligands and Environments

5 bound ligands:
Ligand SO4 5 x SO4
Ligand 64Z 3 x 64Z
Ligand N1S 1 x N1S
Ligand FOF 1 x FOF
Ligand FOH 1 x FOH
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: APS BEAMLINE 21-ID-D
Spacegroup: C2221
Unit cell:
a: 116.45Å b: 222.78Å c: 130.78Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.17 0.169 0.209
Expression system: Escherichia coli

Quick links

Citations

10 review citations

The Paradox of Coenzyme Q10 in Aging.
Díaz-Casado et al. (2019)
9 more

3 mentions without citation

An Isoprene Lipid-Binding Protein Promotes Eukaryotic Coenzyme Q Biosynthesis.
Lohman et al. (2019)
2 more