› 6dhb

X-ray diffraction
1.7Å resolution

Crystal structure of the human TIM-3 with bound Calcium

Released:
DOI: 10.2210/pdb6dhb/pdb
PDB entry 6dhb coloured by chain, front view.
PDB entry 6dhb coloured by chain, side view.
PDB entry 6dhb coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
High resolution X-ray and NMR structural study of human T-cell immunoglobulin and mucin domain containing protein-3.
Gandhi AK, Kim WM, Sun ZJ, Huang YH, Bonsor DA, Sundberg EJ, Kondo Y, Wagner G, Kuchroo VK, Petsko G, Blumberg RS
Sci Rep 8 17512 (2018)
PMID: 30504845

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
  • not assigned
Sequence domains:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-186210 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Hepatitis A virus cellular receptor 2 Chain: A
Molecule details ›
Chain: A
Length: 108 amino acids
Theoretical weight: 12.21 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: Q8TDQ0 (Residues: 24-130; Coverage: 38%)
Gene names: HAVCR2, TIM3, TIMD3
Sequence domains: Immunoglobulin V-set domain
Structure domains: Immunoglobulins

Ligands and Environments

3 bound ligands:
Ligand CA 1 x CA
Ligand BEZ 1 x BEZ
Ligand EDO 2 x EDO
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: APS BEAMLINE 21-ID-G
Spacegroup: P212121
Unit cell:
a: 42.31Å b: 43.06Å c: 51.72Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.152 0.15 0.181
Expression system: Escherichia coli

Quick links

Citations

6 review citations

TIM3 comes of age as an inhibitory receptor.
Wolf et al. (2020)
5 more

4 mentions without citation

TIM-3 as a promising target for cancer immunotherapy in a wide range of tumors.
Sauer et al. (2023)
3 more