› 6dj3

X-ray diffraction
2.6Å resolution

Crystal structure of CNNM2 cyclic nucleotide-binding homology domain

Released:
DOI: 10.2210/pdb6dj3/pdb
PDB entry 6dj3 coloured by chain, front view.
PDB entry 6dj3 coloured by chain, side view.
PDB entry 6dj3 coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
The cyclic nucleotide-binding homology domain of the integral membrane protein CNNM mediates dimerization and is required for Mg2+ efflux activity.
Chen YS, Kozlov G, Fakih R, Funato Y, Miki H, Gehring K
J Biol Chem 293 19998-20007 (2018)
PMID: 30341174

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
Cellular component:
  • not assigned
Sequence domains:

Structure analysis Details

Assembly composition:
homo dimer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-190679 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Metal transporter CNNM2 Chains: A, B
Molecule details ›
Chains: A, B
Length: 199 amino acids
Theoretical weight: 22.73 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli BL21
UniProt:
  • Canonical: Q9H8M5 (Residues: 585-722, 768-822; Coverage: 22%)
Gene names: ACDP2, CNNM2

Ligands and Environments

1 bound ligand:
Ligand EDO 3 x EDO
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: CLSI BEAMLINE 08ID-1
Spacegroup: P3221
Unit cell:
a: 110.582Å b: 110.582Å c: 84.604Å
α: 90° β: 90° γ: 120°
R-values:
R R work R free
0.219 0.219 0.251
Expression system: Escherichia coli BL21

Quick links

Citations

3 review citations

Structural and functional comparison of magnesium transporters throughout evolution.
Franken et al. (2022)
2 more

3 mentions without citation

Current Structural Knowledge on the CNNM Family of Magnesium Transport Mediators.
Giménez-Mascarell et al. (2019)
2 more