› 6dk3

X-ray diffraction
2.04Å resolution

HUMAN MITOCHONDRIAL SERINE HYDROXYMETHYLTRANSFERASe 2

Released:
DOI: 10.2210/pdb6dk3/pdb
PDB entry 6dk3 coloured by chain, front view.
PDB entry 6dk3 coloured by chain, side view.
PDB entry 6dk3 coloured by chain, top view.
Source organism: Homo sapiens
Entry authors: Dong A, Wu H, Zeng H, Loppnau P, Sundstrom M, Arrowsmith CH, Edwards AM, Bochkarev A, Plotnikov AN, Structural Genomics Consortium (SGC)

Function and Biology Details

Reaction catalysed: 
5,10-methylenetetrahydrofolate + glycine + H(2)O = tetrahydrofolate + L-serine
Biochemical function:
Biological process:
Cellular component:
Sequence domains:

Structure analysis Details

Assemblies composition:
monomeric (preferred)
homo dimer
Assembly name:
PDBe Complex ID:
PDB-CPX-152737 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Serine hydroxymethyltransferase, mitochondrial Chain: A
Molecule details ›
Chain: A
Length: 488 amino acids
Theoretical weight: 54.11 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli BL21(DE3)
UniProt:
  • Canonical: P34897 (Residues: 17-504; Coverage: 97%)
Gene name: SHMT2
Sequence domains: Serine hydroxymethyltransferase

Ligands and Environments

1 bound ligand:
Ligand UNX 6 x UNX
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: CHESS BEAMLINE F1
Spacegroup: C2
Unit cell:
a: 95.034Å b: 75.029Å c: 75.199Å
α: 90° β: 108.77° γ: 90°
R-values:
R R work R free
0.198 0.197 0.258
Expression system: Escherichia coli BL21(DE3)

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