› 6dmq

X-ray diffraction
1.7Å resolution

Crystal structure of the T27A mutant of human alpha defensin HNP4.

Released:
DOI: 10.2210/pdb6dmq/pdb
PDB entry 6dmq coloured by chain, front view.
PDB entry 6dmq coloured by chain, side view.
PDB entry 6dmq coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
Systematic mutational analysis of human neutrophil α-defensin HNP4.
Hu H, Di B, Tolbert WD, Gohain N, Yuan W, Gao P, Ma B, He Q, Pazgier M, Zhao L, Lu W
Biochim Biophys Acta Biomembr 1861 835-844 (2019)
PMID: 30658057

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
Cellular component:
Sequence domains:

Structure analysis Details

Assembly composition:
homo dimer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-146340 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Defensin alpha 4 Chains: A, B, C, D, E, F, G, H
Molecule details ›
Chains: A, B, C, D, E, F, G, H
Length: 33 amino acids
Theoretical weight: 3.69 KDa
Source organism: Homo sapiens
Expression system: Not provided
UniProt:
  • Canonical: P12838 (Residues: 64-96; Coverage: 42%)
Gene names: DEF4, DEFA4
Sequence domains: Mammalian defensin

Ligands and Environments

1 bound ligand:
Ligand MPD 1 x MPD
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: SSRL BEAMLINE BL14-1
Spacegroup: P21
Unit cell:
a: 47.704Å b: 38.989Å c: 71.13Å
α: 90° β: 108.93° γ: 90°
R-values:
R R work R free
0.271 0.269 0.31
Expression system: Not provided

Quick links

Citations

2 review citations

Alterations in Immune-Related Defensin Alpha 4 (DEFA4) Gene Expression in Health and Disease.
Basingab et al. (2022)
1 more