› 6dn2

X-ray diffraction
2.88Å resolution

CRYSTAL STRUCTURE OF THE FMN RIBOSWITCH BOUND TO BRX1354 SPLIT RNA

Released:
DOI: 10.2210/pdb6dn2/pdb
Model geometry
Fit model/data
PDB entry 6dn2 coloured by chain, front view.
PDB entry 6dn2 coloured by chain, side view.
PDB entry 6dn2 coloured by chain, top view.
Source organism: Fusobacterium nucleatum
Primary publication:
Structure-Activity Relationship of Flavin Analogues That Target the Flavin Mononucleotide Riboswitch.
Vicens Q, Mondragón E, Reyes FE, Coish P, Aristoff P, Berman J, Kaur H, Kells KW, Wickens P, Wilson J, Gadwood RC, Schostarez HJ, Suto RK, Blount KF, Batey RT
ACS Chem Biol 13 2908-2919 (2018)
PMID: 30107111

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
  • not assigned

Structure analysis Details

Assembly composition:
hetero dimer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-197066 (preferred)
Entry contents:
2 distinct RNA molecules
Macromolecules (2 distinct):
RNA RIBOSWITCH Chain: X
Molecule details ›
Chain: X
Length: 54 nucleotides
Theoretical weight: 17.46 KDa
Source organism: Fusobacterium nucleatum
Expression system: Not provided
RNA (56-MER) Chain: Y
Molecule details ›
Chain: Y
Length: 56 nucleotides
Theoretical weight: 18.09 KDa
Source organism: Fusobacterium nucleatum
Expression system: Not provided

Ligands and Environments

3 bound ligands:
Ligand MG 6 x MG
Ligand GZG 1 x GZG
Ligand K 1 x K
No modified residues

Experiments and Validation Details

wwPDB Validation report is not available for this entry.
X-ray source: RIGAKU RUH3R
Spacegroup: P3121
Unit cell:
a: 71.07Å b: 71.07Å c: 140.48Å
α: 90° β: 90° γ: 120°
R-values:
R R work R free
0.202 0.199 0.257
Expression system: Not provided

Quick links

Citations

9 review citations

Targeting RNA structures with small molecules.
Childs-Disney et al. (2022)
8 more

4 mentions without citation

Riboswitches as Drug Targets for Antibiotics.
Panchal et al. (2021)
3 more