› 6drx

X-ray diffraction
3.1Å resolution

Structural Determinants of Activation and Biased Agonism at the 5-HT2B Receptor

Released:
DOI: 10.2210/pdb6drx/pdb
PDB entry 6drx coloured by chain, front view.
PDB entry 6drx coloured by chain, side view.
PDB entry 6drx coloured by chain, top view.
Source organisms:
Primary publication:
Structural determinants of 5-HT2B receptor activation and biased agonism.
McCorvy JD, Wacker D, Wang S, Agegnehu B, Liu J, Lansu K, Tribo AR, Olsen RHJ, Che T, Jin J, Roth BL
Nat Struct Mol Biol 25 787-796 (2018)
PMID: 30127358

Function and Biology Details

Biochemical function:
Biological process:
Cellular component:
Sequence domains:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-142091 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
5-hydroxytryptamine receptor 2B; Soluble cytochrome b562 Chain: A
Molecule details ›
Chain: A
Length: 410 amino acids
Theoretical weight: 46.05 KDa
Source organisms: Expression system: Spodoptera frugiperda
UniProt:
  • Canonical: P41595 (Residues: 36-248, 314-404; Coverage: 63%)
  • Canonical: P0ABE7 (Residues: 23-123; Coverage: 95%)
Gene names: HTR2B, cybC
Sequence domains:

Ligands and Environments

3 bound ligands:
Ligand H8G 1 x H8G
Ligand CLR 1 x CLR
Ligand OLC 1 x OLC
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: APS BEAMLINE 23-ID-B
Spacegroup: C2221
Unit cell:
a: 59.38Å b: 118.55Å c: 168.203Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.245 0.243 0.286
Expression system: Spodoptera frugiperda

Quick links

Citations

13 review citations

Adhesion G Protein-Coupled Receptors as Drug Targets for Neurological Diseases.
Folts et al. (2019)
12 more

12 mentions without citation

G protein-coupled receptors: structure- and function-based drug discovery.
Yang et al. (2021)
11 more