6du4

X-ray diffraction
1.7Å resolution

Crystal structure of hMettl16 catalytic domain in complex with MAT2A 3'UTR hairpin 1

Released:

Function and Biology Details

Reactions catalysed:
S-adenosyl-L-methionine + adenine in U6 snRNA = S-adenosyl-L-homocysteine + N(6)-methyladenine in U6 snRNA
S-adenosyl-L-methionine + adenine in mRNA = S-adenosyl-L-homocysteine + N(6)-methyladenine in mRNA
Biochemical function:
Biological process:
  • not assigned
Cellular component:
  • not assigned

Structure analysis Details

Assembly composition:
hetero dimer (preferred)
PDBe Complex ID:
PDB-CPX-183226 (preferred)
Entry contents:
1 distinct polypeptide molecule
1 distinct RNA molecule
Macromolecules (2 distinct):
RNA N6-adenosine-methyltransferase METTL16 Chain: A
Molecule details ›
Chain: A
Length: 313 amino acids
Theoretical weight: 35.75 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: Q86W50 (Residues: 1-310; Coverage: 55%)
Gene names: METT10D, METTL16
Sequence domains: RNA methyltransferase
hp1x-RNA (29-MER) Chain: B
Molecule details ›
Chain: B
Length: 29 nucleotides
Theoretical weight: 9.4 KDa
Source organism: Homo sapiens
Expression system: Not provided

Ligands and Environments

2 bound ligands:
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: APS BEAMLINE 19-ID
Spacegroup: P43
Unit cell:
a: 74.979Å b: 74.979Å c: 93.213Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.153 0.152 0.173
Expression systems:
  • Escherichia coli
  • Not provided