› 6dzs

X-ray diffraction
2.62Å resolution

Mycobacterial homoserine dehydrogenase ThrA in complex with NADP

Released:
DOI: 10.2210/pdb6dzs/pdb
PDB entry 6dzs coloured by chain, front view.
PDB entry 6dzs coloured by chain, side view.
PDB entry 6dzs coloured by chain, top view.
Source organism: Mycolicibacterium hassiacum DSM 44199
Entry authors: Chaton CT, Rodriguez ES, Korotkov KV

Function and Biology Details

Reaction catalysed: 
L-homoserine + NAD(P)(+) = L-aspartate 4-semialdehyde + NAD(P)H
Biochemical function:
Biological process:
Cellular component:
  • not assigned
Sequence domains:

Structure analysis Details

Assembly composition:
homo dimer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-125572 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Homoserine dehydrogenase Chains: A, B, C, D
Molecule details ›
Chains: A, B, C, D
Length: 441 amino acids
Theoretical weight: 45.52 KDa
Source organism: Mycolicibacterium hassiacum DSM 44199
Expression system: Escherichia coli BL21(DE3)
UniProt:
  • Canonical: K5BJC9 (Residues: 3-440; Coverage: 100%)
Gene names: C731_3131, MHAS_02717, hom
Sequence domains:
Structure domains:

Ligands and Environments


Cofactor: Ligand NAP 4 x NAP
No bound ligands
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: APS BEAMLINE 22-BM
Spacegroup: P21
Unit cell:
a: 93.8Å b: 110.32Å c: 97.53Å
α: 90° β: 91.83° γ: 90°
R-values:
R R work R free
0.208 0.206 0.245
Expression system: Escherichia coli BL21(DE3)

Quick links