› 6e59

X-ray diffraction
3.4Å resolution

Crystal structure of the human NK1 tachykinin receptor

Released:
DOI: 10.2210/pdb6e59/pdb
PDB entry 6e59 coloured by chain, front view.
PDB entry 6e59 coloured by chain, side view.
PDB entry 6e59 coloured by chain, top view.
Source organisms:
Primary publication:
Crystal structure of the human NK1 tachykinin receptor.
Yin J, Chapman K, Clark LD, Shao Z, Borek D, Xu Q, Wang J, Rosenbaum DM
Proc Natl Acad Sci U S A 115 13264-13269 (2018)
PMID: 30538204

Function and Biology Details

Biochemical function:
Biological process:
Cellular component:
Sequence domains:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-150377 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Starch synthase catalytic domain-containing protein; Substance-P receptor Chain: A
Molecule details ›
Chain: A
Length: 542 amino acids
Theoretical weight: 61.87 KDa
Source organisms: Expression system: Spodoptera aff. frugiperda 2 RZ-2014
UniProt:
  • Canonical: P25103 (Residues: 1-227, 238-346; Coverage: 83%)
  • Canonical: Q9V2J8 (Residues: 218-413; Coverage: 45%)
Gene names: NK1R, PAB2292, TAC1R, TACR1
Sequence domains:

Ligands and Environments

1 bound ligand:
Ligand L76 1 x L76
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: APS BEAMLINE 23-ID-D
Spacegroup: C2
Unit cell:
a: 123.789Å b: 61.975Å c: 142.942Å
α: 90° β: 100.18° γ: 90°
R-values:
R R work R free
0.251 0.248 0.305
Expression system: Spodoptera aff. frugiperda 2 RZ-2014

Quick links

Citations

5 review citations

Understanding Peptide Binding in Class A G Protein-Coupled Receptors.
Tikhonova et al. (2019)
4 more

8 mentions without citation

G protein-coupled receptors: structure- and function-based drug discovery.
Yang et al. (2021)
7 more