› 6e6z

X-ray diffraction
1.75Å resolution

Structure of Wild Type Human Transthyretin in Complex with Tafamidis

Released:
DOI: 10.2210/pdb6e6z/pdb
PDB entry 6e6z coloured by chain, front view.
PDB entry 6e6z coloured by chain, side view.
PDB entry 6e6z coloured by chain, top view.
Source organism: Homo sapiens
Entry authors: Chung K, Saelices L, Sawaya MR, Cascio D, Eisenberg D

Function and Biology Details

Biochemical function:
Biological process:
Cellular component:
Sequence domains:

Structure analysis Details

Assembly composition:
homo tetramer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-136168 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Transthyretin Chains: A, B
Molecule details ›
Chains: A, B
Length: 115 amino acids
Theoretical weight: 12.61 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: P02766 (Residues: 30-144; Coverage: 91%)
Gene names: PALB, TTR
Sequence domains: HIUase/Transthyretin family

Ligands and Environments

1 bound ligand:
Ligand 3MI 2 x 3MI
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: APS BEAMLINE 24-ID-C
Spacegroup: P21212
Unit cell:
a: 41.24Å b: 84.26Å c: 63.43Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.195 0.192 0.223
Expression system: Escherichia coli

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