› 6e8f

X-ray diffraction
2.99Å resolution

Crystal Structure of Human Protocadherin-15 EC3-5 CD2-1

Released:
DOI: 10.2210/pdb6e8f/pdb
PDB entry 6e8f coloured by chain, front view.
PDB entry 6e8f coloured by chain, side view.
PDB entry 6e8f coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
Structural determinants of protocadherin-15 mechanics and function in hearing and balance perception.
Choudhary D, Narui Y, Neel BL, Wimalasena LN, Klanseck CF, De-la-Torre P, Chen C, Araya-Secchi R, Tamilselvan E, Sotomayor M
Proc Natl Acad Sci U S A 117 24837-24848 (2020)
PMID: 32963095

Function and Biology Details

Biochemical function:
Biological process:
Cellular component:
Sequence domains:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-188706 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Protocadherin-15 Chains: A, B, C
Molecule details ›
Chains: A, B, C
Length: 362 amino acids
Theoretical weight: 40.41 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli BL21
UniProt:
  • Canonical: Q96QU1 (Residues: 263-435, 436-608; Coverage: 18%)
Gene names: PCDH15, USH1F
Sequence domains: Cadherin domain

Ligands and Environments

2 bound ligands:
Ligand CA 13 x CA
Ligand NA 1 x NA
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: APS BEAMLINE 24-ID-C
Spacegroup: P2221
Unit cell:
a: 95.735Å b: 95.906Å c: 258.604Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.176 0.174 0.214
Expression system: Escherichia coli BL21

Quick links

Citations

4 review citations

Mechanotransduction in mammalian sensory hair cells.
Caprara et al. (2022)
3 more