› 6e8m

X-ray diffraction
1.61Å resolution

Legionella Longbeachae LeSH (Llo2327) bound to the human DnaJ-A1 pTyr381 peptide

Released:
DOI: 10.2210/pdb6e8m/pdb
PDB entry 6e8m coloured by chain, front view.
PDB entry 6e8m coloured by chain, side view.
PDB entry 6e8m coloured by chain, top view.
Source organisms:
Primary publication:
Identification and characterization of a large family of superbinding bacterial SH2 domains.
Kaneko T, Stogios PJ, Ruan X, Voss C, Evdokimova E, Skarina T, Chung A, Liu X, Li L, Savchenko A, Ensminger AW, Li SS
Nat Commun 9 4549 (2018)
PMID: 30382091

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
  • not assigned
Sequence domains:

Structure analysis Details

Assembly composition:
hetero dimer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-112496 (preferred)
Entry contents:
2 distinct polypeptide molecules
Macromolecules (2 distinct):
SH2 domain-containing protein Chain: A
Molecule details ›
Chain: A
Length: 169 amino acids
Theoretical weight: 19.77 KDa
Source organism: Legionella longbeachae NSW150
Expression system: Escherichia coli
UniProt:
  • Canonical: D3HJY4 (Residues: 1-167; Coverage: 100%)
Gene name: LLO_2327
Sequence domains: SH2 domain
DnaJ homolog subfamily A member 1 Chain: B
Molecule details ›
Chain: B
Length: 13 amino acids
Theoretical weight: 1.7 KDa
Source organism: Homo sapiens
Expression system: Not provided
UniProt:
  • Canonical: P31689 (Residues: 375-387; Coverage: 3%)
Gene names: DNAJ2, DNAJA1, HDJ2, HSJ2, HSPF4

Ligands and Environments

No bound ligands
1 modified residue:
Ligand PTR 1 x PTR

Experiments and Validation Details

Entry percentile scores
X-ray source: RIGAKU RUH3R
Spacegroup: P212121
Unit cell:
a: 40.9Å b: 64.71Å c: 67.85Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.199 0.199 0.212
Expression systems:
  • Escherichia coli
  • Not provided

Quick links

Citations

3 review citations

Molecular Mimicry: a Paradigm of Host-Microbe Coevolution Illustrated by Legionella.
Mondino et al. (2020)
2 more