› 6ecm

X-ray diffraction
2.35Å resolution

Crystal Structure of SNX15 PX domain in domain swapped conformation

Released:
DOI: 10.2210/pdb6ecm/pdb
PDB entry 6ecm coloured by chain, front view.
PDB entry 6ecm coloured by chain, side view.
PDB entry 6ecm coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
Classification of the human phox homology (PX) domains based on their phosphoinositide binding specificities.
Chandra M, Chin YK, Mas C, Feathers JR, Paul B, Datta S, Chen KE, Jia X, Yang Z, Norwood SJ, Mohanty B, Bugarcic A, Teasdale RD, Henne WM, Mobli M, Collins BM
Nat Commun 10 1528 (2019)
PMID: 30948714

Function and Biology Details

Biochemical function:
Biological process:
  • not assigned
Cellular component:
  • not assigned
Sequence domains:

Structure analysis Details

Assembly composition:
homo dimer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-192569 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Sorting nexin-15 Chain: A
Molecule details ›
Chain: A
Length: 128 amino acids
Theoretical weight: 15.13 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: Q9NRS6 (Residues: 1-126; Coverage: 37%)
Gene name: SNX15
Sequence domains: PX domain

Ligands and Environments

1 bound ligand:
Ligand SO4 1 x SO4
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: AUSTRALIAN SYNCHROTRON BEAMLINE MX2
Spacegroup: P43212
Unit cell:
a: 54.498Å b: 54.498Å c: 83.58Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.25 0.244 0.299
Expression system: Escherichia coli

Quick links

Citations

26 review citations

Novel roles of phosphoinositides in signaling, lipid transport, and disease.
Hammond et al. (2020)
25 more

3 mentions without citation

Classification of the human phox homology (PX) domains based on their phosphoinositide binding specificities.
Chandra et al. (2019)
2 more