› 6ed6

X-ray diffraction
2.86Å resolution

Function and Biology Details

Reaction catalysed: 
ATP + a protein = ADP + a phosphoprotein
Biochemical function:
Biological process:
Cellular component:
  • not assigned
Sequence domains:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-130835 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Rho-associated protein kinase 2 Chains: A, B
Molecule details ›
Chains: A, B
Length: 415 amino acids
Theoretical weight: 48.06 KDa
Source organism: Homo sapiens
Expression system: Trichoplusia ni
UniProt:
  • Canonical: O75116 (Residues: 27-417; Coverage: 28%)
Gene names: KIAA0619, ROCK2
Sequence domains: Protein kinase domain

Ligands and Environments

1 bound ligand:
Ligand J0P 2 x J0P
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: APS BEAMLINE 21-ID-G
Spacegroup: P212121
Unit cell:
a: 53.446Å b: 136.672Å c: 148.691Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.206 0.204 0.247
Expression system: Trichoplusia ni

Quick links

Citations

1 review citation

The pyridazine heterocycle in molecular recognition and drug discovery.
Meanwell NA. (2023)
5 other articles

6 mentions without citation

RSK1 vs. RSK2 Inhibitory Activity of the Marine β-Carboline Alkaloid Manzamine A: A Biochemical, Cervical Cancer Protein Expression, and Computational Study.
Mayer et al. (2021)
5 more