› 6eel

X-ray diffraction
1.93Å resolution

Crystal Structure of Myoferlin C2A with divalent cation

Released:
DOI: 10.2210/pdb6eel/pdb
PDB entry 6eel coloured by chain, front view.
PDB entry 6eel coloured by chain, side view.
PDB entry 6eel coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
Structural Basis for the Distinct Membrane Binding Activity of the Homologous C2A Domains of Myoferlin and Dysferlin.
Harsini FM, Bui AA, Rice AM, Chebrolu S, Fuson KL, Turtoi A, Bradberry M, Chapman ER, Sutton RB
J Mol Biol 431 2112-2126 (2019)
PMID: 31004665

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
  • not assigned
Sequence domains:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-192765 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Myoferlin Chains: A, B, C
Molecule details ›
Chains: A, B, C
Length: 129 amino acids
Theoretical weight: 14.26 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: Q9NZM1 (Residues: 1-125; Coverage: 6%)
Gene names: FER1L3, KIAA1207, MYOF
Sequence domains: C2 domain
Structure domains: C2 domain

Ligands and Environments

1 bound ligand:
Ligand SR 6 x SR
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: SSRL BEAMLINE BL7-1
Spacegroup: P212121
Unit cell:
a: 47.35Å b: 83.11Å c: 94.28Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.186 0.181 0.232
Expression system: Escherichia coli

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Citations

6 review citations

The Dystrophin Node as Integrator of Cytoskeletal Organization, Lateral Force Transmission, Fiber Stability and Cellular Signaling in Skeletal Muscle.
Dowling et al. (2021)
5 more

2 mentions without citation

Structural Basis for the Distinct Membrane Binding Activity of the Homologous C2A Domains of Myoferlin and Dysferlin.
Harsini et al. (2019)
1 more