› 6eet

X-ray diffraction
3.23Å resolution

Crystal structure of mouse Protocadherin-15 EC9-MAD12

Released:
DOI: 10.2210/pdb6eet/pdb
PDB entry 6eet coloured by chain, front view.
PDB entry 6eet coloured by chain, side view.
PDB entry 6eet coloured by chain, top view.
Source organism: Mus musculus
Primary publication:
Structural determinants of protocadherin-15 mechanics and function in hearing and balance perception.
Choudhary D, Narui Y, Neel BL, Wimalasena LN, Klanseck CF, De-la-Torre P, Chen C, Araya-Secchi R, Tamilselvan E, Sotomayor M
Proc Natl Acad Sci U S A 117 24837-24848 (2020)
PMID: 32963095

Function and Biology Details

Biochemical function:
Biological process:
Cellular component:
Sequence domains:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-189381 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecules (2 distinct):
Protocadherin-15 Chain: A
Molecule details ›
Chain: A
Length: 474 amino acids
Theoretical weight: 52.92 KDa
Source organism: Mus musculus
Expression system: Homo sapiens
UniProt:
  • Canonical: Q99PJ1 (Residues: 924-1379; Coverage: 24%)
Gene name: Pcdh15
Sequence domains: Cadherin domain

Ligands and Environments

Carbohydrate polymer : NEW Components: NAG
Carbohydrate polymer
3 bound ligands:
Ligand MAN 3 x MAN
Ligand EPE 1 x EPE
Ligand CA 4 x CA
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: APS BEAMLINE 24-ID-E
Spacegroup: C2221
Unit cell:
a: 129.507Å b: 170.059Å c: 91.528Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.179 0.176 0.234
Expression system: Homo sapiens

Quick links

Citations

4 review citations

Mechanotransduction in mammalian sensory hair cells.
Caprara et al. (2022)
3 more