› 6efd

X-ray diffraction
1.85Å resolution

Hsa Siglec and Unique domains in complex with the sialyl T antigen trisaccharide

Released:
DOI: 10.2210/pdb6efd/pdb
Model geometry
Fit model/data
PDB entry 6efd coloured by chain, front view.
PDB entry 6efd coloured by chain, side view.
PDB entry 6efd coloured by chain, top view.
Source organism: Streptococcus gordonii str. Challis
Primary publication:
Origins of glycan selectivity in streptococcal Siglec-like adhesins suggest mechanisms of receptor adaptation.
Bensing BA, Stubbs HE, Agarwal R, Yamakawa I, Luong K, Solakyildirim K, Yu H, Hadadianpour A, Castro MA, Fialkowski KP, Morrison KM, Wawrzak Z, Chen X, Lebrilla CB, Baudry J, Smith JC, Sullam PM, Iverson TM
OpenAccess logo Nat Commun 13 2753 (2022)
PMID: 35585145

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
  • not assigned
Sequence domains:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-108566 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecules (2 distinct):
Streptococcal hemagglutinin Chain: A
Molecule details ›
Chain: A
Length: 234 amino acids
Theoretical weight: 25.84 KDa
Source organism: Streptococcus gordonii str. Challis
Expression system: Escherichia coli
UniProt:
  • Canonical: A8AWU7 (Residues: 220-453; Coverage: 11%)
Gene names: SGO_0966, hsa
Sequence domains:

Ligands and Environments

Carbohydrate polymer : NEW Components: A2G, GAL, SIA
Carbohydrate polymer
1 bound ligand:
Ligand NA 2 x NA
No modified residues

Experiments and Validation Details

wwPDB Validation report is not available for this entry.
X-ray source: APS BEAMLINE 21-ID-G
Spacegroup: P212121
Unit cell:
a: 46.645Å b: 58.14Å c: 75.959Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.197 0.196 0.218
Expression system: Escherichia coli

Quick links

Citations

2 review citations

Mutexa: A Computational Ecosystem for Intelligent Protein Engineering.
Yang et al. (2023)
1 more

3 mentions without citation

Molecular recognition of sialoglycans by streptococcal Siglec-like adhesins: toward the shape of specific inhibitors.
Di Carluccio et al. (2021)
2 more