› 6eh4

X-ray diffraction
1.26Å resolution

003 Human T-Cell Receptor specific for HIV GAG epitope SLYNTVATL carried by Human Leukocyte Antigen HLA-A*0201

Released:
DOI: 10.2210/pdb6eh4/pdb
Model geometry
Fit model/data
PDB entry 6eh4 coloured by chain, front view.
PDB entry 6eh4 coloured by chain, side view.
PDB entry 6eh4 coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
In Silico and Structural Analyses Demonstrate That Intrinsic Protein Motions Guide T Cell Receptor Complementarity Determining Region Loop Flexibility.
Holland CJ, MacLachlan BJ, Bianchi V, Hesketh SJ, Morgan R, Vickery O, Bulek AM, Fuller A, Godkin A, Sewell AK, Rizkallah PJ, Wells S, Cole DK
OpenAccess logo Front Immunol 9 674 (2018)
PMID: 29696015

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
  • not assigned
Sequence domains:

Structure analysis Details

Assembly composition:
hetero dimer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-214027 (preferred)
Entry contents:
2 distinct polypeptide molecules
Macromolecules (2 distinct):
Human T Cell Receptor Alpha Chain Chain: D
Molecule details ›
Chain: D
Length: 204 amino acids
Theoretical weight: 22.41 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
Structure domains: Immunoglobulins
Human T Cell Receptor Beta Chain Chain: E
Molecule details ›
Chain: E
Length: 244 amino acids
Theoretical weight: 27.45 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
Structure domains: Immunoglobulins

Ligands and Environments

2 bound ligands:
Ligand GOL 3 x GOL
Ligand EDO 5 x EDO
No modified residues

Experiments and Validation Details

wwPDB Validation report is not available for this entry.
X-ray source: DIAMOND BEAMLINE I04-1
Spacegroup: P21
Unit cell:
a: 43.23Å b: 81.22Å c: 65.07Å
α: 90° β: 90.3° γ: 90°
R-values:
R R work R free
0.16 0.159 0.191
Expression system: Escherichia coli

Quick links

Citations

3 review citations

Structural understanding of T cell receptor triggering.
Xu et al. (2020)
2 more

1 mention without citation

In Silico and Structural Analyses Demonstrate That Intrinsic Protein Motions Guide T Cell Receptor Complementarity Determining Region Loop Flexibility.
Holland et al. (2018)